Endocrine Abstracts

Introduction: The most frequent causes of hypercalcemia in the general population are primary hyperparathyroidism and malignancies. However, we must sometimes consider other causes, such as Cushing’s syndrome.Clinical case: A 49-year-old man who was being assessed for hypertrophic cardiomyopathy was referred to our Endocrinology Clinic in order to investigate the incidental finding of hypercalcemia (11.08 mg/dl) with high PTH (84.6 pg/ml), hypophosp...

Objectives: Main: To assess the effect on the 10-year risk of cardiovascular events (RCVE) of daily supplementation with a fixed combination of red yeast rice extract (250 mg), berberin 525 mg and coenzyme Q10 (50 mg) in patients with self-reported statin intolerance. Secondary: effects on anthropometric (BMI, SBP, DBP, HR) and laboratory (lipids, fasting glucose and HbA1C in diabetic patients, eGFR, AST, ALT, GGT, CK); self-reported compliance and tolera...

Introduction: Intracranial Idiopathic Hypertension (IIH) is a rare complication of testosterone therapy. It is usually benign, but may result and permanent blindness. Its diagnosis is based on a high CSF (> 25 cm H2O) pressure, in the absence of specific causes. The androgen receptor is expressed in the human choroid plexus, and may enhance the activity of Na+/K+-ATPase, and therefore CSF secretion.Methods: Review of the patient’s cli...

Introduction: The 48XXXY karyotype is an infrequent (incidence about 1/50000 male births) sporadic aneuploidy of the sex chromosomes, classically considered as a variant of the Klinefelter syndrome (47XXY). Although many of their characteristics are shared, patients with the 48XXXY karyotype suffer from additional endocrinological and neuropsychological disturbances which are not part of the classic Klinefelter syndrome. Hereby we present a clinical case.<p class="abstext"...

Introduction: Oral semaglutide has been available in the Spanish market since November 2021. This new formulation has broken the self-injection barrier, and may enhance patient satisfaction.Methods: Retrospective review of the patients′ records and presential or telephonic interviews. All patients expressed their consent for the anonymous processing of their data. Numeric data are given as mean + s.d; paired t-test was used for comparison. Satisfac...

Introduction: Vitamin D deficiency is associated with higher risk of severe COVID-19, and type 2 diabetic patients are a vulnerable group. We described an alarming rate of vitamin D deficiency (around 80.0% with plasma calcifediol <30 ng/ml) in unsupplemented type 2 diabetes patients during the 2020 spring lockdown and the following winter in Northern Gran Canaria. There is an increasing awareness of this problem, both in family physicians and the general population, and t...

Introduction: During most of the autumn of 2022, the standard maintenance presentation of parenteral semaglutide (1.0 mg for weekly dosage) was temporarily unavailable. Many of the patients using this dose were switched to the standard maintenance dose of oral semaglutide (14 mg daily). The leaflet included with the product specifies that the 14 mg daily oral dose is equivalent to the 0.5 mg parenteral weekly dose, but this is most likely an interpolation, as there are no repo...

Introduction/Aim: New oral anticoagulant drugs such as the factor Xa inhibitor rivaroxaban are often preferred to the classic coumarins because they do not need frequent blood-test monitoring and have fever interactions with other drugs and foodstuffs. They are not, however, interaction free. Rivaroxaban is metabolized by oxidative degradation catalyzed by CYP3A4/5 and CYP2J2; it is also a substrate of the P-gp and ABCG2 efflux transporter proteins. CYP3A4 activity enhancers s...

Introduction: Acromegaly is associated with many different types of benign and malign neoplasm, putatively because of the chronic elevation of IGF-1. Colorectal, thyroid and breast neoplasms are well-established associations; there are many other possible ones, such as prostatic and uterine neoplasms, meningioma, leukemia, lymphoma, renal, pulmonary, esophageal and gastric tumors. Also in the context of MEN-1, parathyroid and pancreatic neoplasms are associated with acromegaly...

Objective: Functional hypercortisolism associated with alcohol abuse is an infrequently diagnosed entity of unknown prevalence. Ethanol elicits hypothalamic oversecretion of CRH with subsequent increase in ACTH and cortisol. It may simulate Cushing’s disease both clinically and biochemically but there are no anatomic lesions and the diagnosis is confirmed by normalization of the biochemical pattern after at least 1 month of abstinence from alcohol. We hereby report a clin...